Methods the rats model of hot-stomach syndrome was established by oral administration with anhydrous alcohol and pepper decoction; And the rats model of cold-stomach syndrome was established by oral administration with ice water and sodium hydroxide. 方法选用SD大鼠,以辣椒煎液和无水乙醇造成胃热证模型,以冰水和氢氧化钠造成胃寒证模型,比较左金丸和反左金对两个模型胃黏膜损伤的防治作用。